Concepedia

Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression

Himalaya Parajuli, Muy‐Teck Teh, Siren Abrahamsen, I Christoffersen, Evelyn Neppelberg, Stein Lybak, Tarig Osman, A. C. Johannessen, Donald Gullberg, Kathrine Skarstein,

Journal of Oral Pathology and Medicine · 2016 · 70 citations · 23 references

DOIFull text

Open access

Abstract

Integrin α11 was overexpressed in HNSCC stroma and colocalized with α-SMA. Expression of α-SMA at tumour front but not tumour centre had prognostic value for survival, pinpointing the importance of assessing tumour front when evaluating stromal molecules as prognostic biomarkers.

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