The Effects of Syzygium samarangense, Passiflora edulis and Solanum muricatum on Alcohol-Induced Liver Injury

Abstract

Previous studies have shown that fruits have different effects on alcohol metabolism and alcohol-induced liver injury. The present work selected three fruits and aimed at studying the effects of <i>Syzygium samarangense</i>, <i>Passiflora edulis</i> and <i>Solanum muricatum</i> on alcohol-induced liver injury in mice. The animals were treated daily with alcohol and fruit juices for fifteen days. Chronic treatment with alcohol increased the levels of aspartate transaminase (AST), alanine transaminase (ALT), total bilirubin (TBIL), triglyceride (TG), malondialdehyde (MDA), and decreased total protein (TP). Histopathological evaluation also showed that ethanol induced extensive fat droplets in hepatocyte cytoplasm. <i>Syzygium samarangense</i> and <i>Passiflora edulis</i> normalized various biochemical parameters. <i>Solanum muricatum</i> increased the level of ALT and induced infiltration of inflammatory cells in the liver. These results strongly suggest that treatment with <i>Syzygium samarangense</i> and <i>Passiflora edulis</i> could protect liver from the injury of alcohol, while <i>Solanum muricatum</i> could aggravate the damage.