Synergistic reactivation of latent HIV-1 provirus by PKA activator dibutyryl-cAMP in combination with an HDAC inhibitor

Long-term follow-up studies confirm the stability of the latent reservoir for HIV-1 in resting CD4+ T cells

Janet D. Siliciano, Joleen Kajdas, Diana Finzi et al. · Nature Medicine · 2003 · 1.7K citations

Life Sciences, Immunology, Infectious Diseases +15

HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation

Nicolas Chomont, Mohamed El‐Far, Petronela Ancuța et al. · Nature Medicine · 2009 · 1.7K citations · Full text

Life Sciences, Immunology, Infectious Diseases +16

Administration of vorinostat disrupts HIV-1 latency in patients on antiretroviral therapy

Nancie M. Archin, Abigail Liberty, Angela D. M. Kashuba et al. · Nature · 2012 · 1.2K citations

Pharmacy, Pharmacokinetics, Pharmacology +12

Severe CD4⁺T-Cell Depletion in Gut Lymphoid Tissue during Primary Human Immunodeficiency Virus Type 1 Infection and Substantial Delay in Restoration following Highly Active Antiretroviral Therapy

Moraima Guadalupe, Elizabeth Reay, Sumathi Sankaran et al. · Journal of Virology · 2003 · 864 citations · Full text

Life Sciences, Infectious Diseases, Cellular Immunology +16

Stimulation of HIV-1-Specific Cytolytic T Lymphocytes Facilitates Elimination of Latent Viral Reservoir after Virus Reactivation

Liang Shan, Kai Deng, Neeta S. Shroff et al. · Immunity · 2012 · 707 citations · Full text

Life Sciences, Immunology, Infectious Diseases +14