Choline Transporter-Like Protein-2

Behnaz Bayat, Yudy Tjahjono, Heike Berghöfer, Silke Werth, Hans Deckmyn, Simon F. De Meyer, Ulrich J. Sachs, Sentot Santoso

Arteriosclerosis Thrombosis and Vascular Biology · 2015 · 36 citations · 25 references

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Abstract

We introduce CTL-2 as a new binding partner for VWF. Interaction of neutrophils with VWF via CTL-2 allows anti-HNA-3a to induce signal transduction via CD11b/CD18, which leads to neutrophil activation and agglutination. In transfusion-related acute lung injury, this mechanism may further aggravate endothelial leakage.

References

25