Causative factors and epidemiology of bilateral vestibulopathy in 255 patients

TLDR

The study aims to identify the causes and epidemiology of bilateral vestibulopathy in 255 patients. A retrospective review of 255 BV patients was conducted, with each undergoing standardized neuroophthalmological and neurootological examinations, electronystagmography, cranial MRI/CT, and laboratory tests. Definite causes were identified in 24% and probable in 25%, with ototoxic aminoglycosides, Menière's disease, and meningitis being most common; 25% displayed cerebellar signs, which were linked to peripheral polyneuropathy in 32% versus 18% without cerebellar signs, and hypoacusis occurred bilaterally in 25%; overall, the etiology remains unclear in about half the patients, and the frequent co‑occurrence of cerebellar dysfunction and polyneuropathy points to a potential neurodegenerative or autoimmune syndrome.

Abstract

To determine the causative factors and epidemiology of bilateral vestibulopathy (BV).This is a retrospective review of 255 patients (mean age, 62 +/- 16 years) with BV diagnosed in our dizziness unit between 1988 and 2005. All patients had undergone a standardized neurophthalmological and neurootological examination, electronystagmography with caloric irrigation, cranial magnetic resonance imaging or computed tomography (n = 214), and laboratory tests.Sixty-two percent of the study population were male subjects. Previous vertigo attacks had occurred in 36%, indicating a sequential manifestation. The definite cause of BV was determined in 24% and the probable cause in 25%: The most common causes were ototoxic aminoglycosides (13%), Menière's disease (7%), and meningitis (5%). Strikingly, 25% exhibited cerebellar signs. Cerebellar dysfunction was associated with peripheral polyneuropathy in 32% compared with 18% in BV patients without cerebellar signs. Hypoacusis occurred bilaterally in 25% and unilaterally in 6% of all patients. It appeared most often in patients with BV caused by Cogan's syndrome, meningitis, or Menière's disease.The cause of BV remains unclear in about half of all patients despite intensive examinations. A large subgroup of these patients have associated cerebellar dysfunction and peripheral polyneuropathy. This suggests a new syndrome that may be caused by neurodegenerative or autoimmune processes.