Screening for <i><scp>ROS</scp>1</i> gene rearrangements in non‐small‐cell lung cancers using immunohistochemistry with <scp>FISH</scp> confirmation is an effective method to identify this rare target

Abstract

ROS1 rearrangements are rare events in lung adenocarcinomas. Selection of cases for ROS1 FISH testing, by excluding EGFR/ALK-positive cases and use of IHC to screen for potentially positive cases, can be used to enrich for the likelihood of identifying a ROS1 rearranged lung cancer and prevent the need to undertake expensive and time-consuming FISH testing in all cases.