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A Nonparametric Method to Optimize Initial Drug Dosing and Attainment of a Target Exposure Interval: Concepts and Application to Busulfan in Pediatrics

Drug SafetyTarget Exposure IntervalPharmacokinetic ModelingPharmacological StudyMedicinePediatricsInitial Drug DosingNonparametric MethodToxicologyPharmacotherapyPharmacodynamic ModelingPharmacologyPharmacological IssuePharmacokineticsDrug Discovery