Risks of first and subsequent cancers among <i>TP53</i> mutation carriers in the National Cancer Institute Li‐Fraumeni syndrome cohort

Abstract

The cumulative cancer risk in TP53 + individuals was very high and varied by sex, age, and cancer type. Additional work, including prospective risk estimates, is needed to better inform personalized risk management. Cancer 2016;122:3673-81. © 2016 American Cancer Society.