The 5-HT<sub>1A</sub>Receptor PET Radioligand<sup>11</sup>C-CUMI-101 Has Significant Binding to α<sub>1</sub>-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region - Concepedia

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The 5-HT<sub>1A</sub>Receptor PET Radioligand<sup>11</sup>C-CUMI-101 Has Significant Binding to α<sub>1</sub>-Adrenoceptors in Human Cerebellum, Limiting Its Use as a Reference Region

DOI Full Paper Access

10

Citations

10

References

2016

Year

Saurav Shrestha, Jeih‐San Liow, Kimberly J. Jenko, Masamichi Ikawa, Sami S. Zoghbi, Robert B. Innis

Journal of Nuclear Medicine

Abstract

Reasoning by analogy, 25% of <sup>11</sup>C-CUMI-101 uptake in human cerebellum reflects binding to α<sub>1</sub>-adrenoceptors, suggesting that the cerebellum is of limited usefulness as a reference tissue for quantification in human studies.

References

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