Concepedia

Pre-clinical risk assessment and therapeutic potential of antitumor lipopeptide ‘Iturin A’ in an in vivo and in vitro model

Goutam Dey, Rashmi Bharti, Indranil Banerjee, Anjan Kumar Das, Chandan Kanta Das, Subhayan Das, Bikash Chandra Jena, Mridula Misra, Ramkrishna Sen, Mahitosh Mandal

RSC Advances · 2016 · 29 citations · 16 references

DOI

Concepts

Abstract

Microbial lipopeptide “Iturin A” is a versatile bio-active molecule with potent antitumor action. Pre-clinical study of this lipopeptide showed very minimum toxicity in rodent model.

References

16

Preparation, characterization and biodistribution of ultrafine chitosan nanoparticles

Tanima Banerjee, Susmita Mitra, Ajay Singh et al. · International Journal of Pharmaceutics · 2002 · 404 citations

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Antineoplastic and Apoptotic Potential of Traditional Medicines Thymoquinone and Diosgenin in Squamous Cell Carcinoma

Subhasis Das, Kaushik Dey, Goutam Dey et al. · PLoS ONE · 2012 · 157 citations · Full text

Apratoxin A Reversibly Inhibits the Secretory Pathway by Preventing Cotranslational Translocation

Yanxia Liu, Brian K. Law, Hendrik Luesch · Molecular Pharmacology · 2009 · 144 citations

Marine lipopeptide Iturin A inhibits Akt mediated GSK3β and FoxO3a signaling and triggers apoptosis in breast cancer

Goutam Dey, Rashmi Bharti, Gunaseelan Dhanarajan et al. · Scientific Reports · 2015 · 126 citations · Full text

The marine lipopeptide somocystinamide A triggers apoptosis via caspase 8

Wolf Wrasidlo, Ainhoa Mielgo, Vicente A. Torres et al. · Proceedings of the National Academy of Sciences · 2008 · 116 citations · Full text

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