Concepedia

Tumor necrosis factor alpha, citrullination, and peptidylarginine deiminase 4 in lung and joint inflammation

Mandar Bawadekar, Annette Gendron‐Fitzpatrick, Ryan J. Rebernick, Daeun Shim, Thomas F. Warner, Anthony P. Nicholas, Lennart K. A. Lundblad, Paul R. Thompson, Miriam A. Shelef

Arthritis Research & Therapy · 2016 · 40 citations · 43 references

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Abstract

PAD4 exacerbates lung inflammation downstream of TNF-α without having a major role in generalized protein citrullination in inflamed lungs. Also, TNF-α-induced lung inflammation is not sufficient to drive murine arthritis.

References

43

Transgenic mice expressing human tumour necrosis factor: a predictive genetic model of arthritis.

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A new model for an etiology of rheumatoid arthritis: Smoking may trigger HLA–DR (shared epitope)–restricted immune reactions to autoantigens modified by citrullination

Lars Klareskog, Patrik Stolt, Karin Lundberg et al. · Arthritis & Rheumatism · 2005 · 1.5K citations

PAD4 is essential for antibacterial innate immunity mediated by neutrophil extracellular traps

Pingxin Li, Ming Li, Michael Lindberg et al. · The Journal of Experimental Medicine · 2010 · 1.4K citations · Full text

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NETs Are a Source of Citrullinated Autoantigens and Stimulate Inflammatory Responses in Rheumatoid Arthritis

Ritika Khandpur, Carmelo Carmona‐Rivera, Anuradha Vivekanandan‐Giri et al. · Science Translational Medicine · 2013 · 1.3K citations · Full text

Functional haplotypes of PADI4, encoding citrullinating enzyme peptidylarginine deiminase 4, are associated with rheumatoid arthritis

Akari Suzuki, Ryo Yamada, Xiaotian Chang et al. · Nature Genetics · 2003 · 1.2K citations

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