One‐pot synthesis of 3,4‐dihydropyridin‐2‐ones via tandem reaction of Blaise reactionintermediate and acrylic ester

Abstract

An efficient method for the synthesis 3,4‐dihydropyridin‐2‐ones has been developed via tandem one‐pot Michael‐type addition and cyclization of the Blaise reaction intermediate and acrylic ester. A series of readily available nitriles, bromoacetic esters and acrylic esters have been employed to examine the scope of substrates for this method. Copyright © 2015 John Wiley & Sons, Ltd.