Trypsin inhibitors for the treatment of pancreatitis

Hereditary pancreatitis is caused by a mutation in the cationic trypsinogen gene

David C. Whitcomb, Michael C. Gorry, Robert A. Preston et al. · Nature Genetics · 1996 · 1.6K citations

Medicine, Genetics, Molecular Genetics +12

Hereditary pancreatitis caused by triplication of the trypsinogen locus

Cédric Le Maréchal, Emmanuelle Masson, Jian‐Min Chen et al. · Nature Genetics · 2006 · 203 citations

Medicine, Genetics, Molecular Genetics +11

Acute pancreatitis: diagnosis, prognosis, and treatment.

Jennifer K. Carroll, Brian Herrick, Teresa Gipson et al. · PubMed · 2007 · 170 citations

Medicine, Internal Medicine, Pathology +15

Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): A highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes

Tomohiro Yoshida, Fumihiko Akahoshi, Hiroshi Sakashita et al. · Bioorganic & Medicinal Chemistry · 2012 · 150 citations · Full text

Medicine, Medicinal Chemistry, Pharmacology +6

Reducing Extracellular pH Sensitizes the Acinar Cell to Secretagogue-Induced Pancreatitis Responses in Rats

Madhavi Bhoomagoud, Thomas Jung, Jórunn Atladóttir et al. · Gastroenterology · 2009 · 115 citations · Full text

Life Sciences, Pharmacology, Physiology +16