New insights in the molecular signature of advanced medullary thyroid cancer: evidence of a bad outcome of cases with double <i>RET</i> mutations

Abstract

This study showed a high prevalence of somatic <i>RET</i> mutations in advanced and metastatic MTCs. <i>RAS</i> mutations were present in a small percentage of cases and mutually exclusive with <i>RET</i> mutations. In a small number of cases, more than one <i>RET</i> mutation was present in the same tissue. <i>RET</i> double mutations and, to a lesser extent, also complex mutations showed a worse outcome.