Epileptic Activity Increases Cerebral Amino Acid Transport Assessed by ¹⁸F-Fluoroethyl-l-Tyrosine Amino Acid PET: A Potential Brain Tumor Mimic

Abstract

Seizure activity, in particular status epilepticus, increases cerebral amino acid transport with a strict gyral ¹⁸F-FET uptake pattern. Such periictal pseudoprogression represents a potential pitfall of ¹⁸F-FET PET and may mimic brain tumor. Our data also indicate a seizure-induced upregulation of neuronal, endothelial, and less astroglial LAT1/LAT2/CD98 amino acid transporter expression.