Lysosomal hydrolases in established lymphoid cell lines.

Abstract

The activity of lysosomal acid hydrolases was determined in five established lymphoid lines. Of four B cell lines three contained the EBV genome, and one was an EBV free Burkitt derived lymphoma line. The fifth was derived from acute lymphoblastic leukaemia expressing T cell characteristics. Ten enzymes were assayed in extracts from each cell line. Wide dispersions have been observed between the five lines. The activity level of most enzymes was lower in lymphoid lines than in leukocytes or fibroblasts, and in lines derived from pathological cells from normal cells.