Recent aspects of prostaglandin biosynthesis: a review.

Abstract

Some recent aspects of prostaglandin biosynthesis of physiological importance are reviewed. Particular attention has been placed on phospholipase functioning and inhibition, endoperoxides, thromboxane and prostacyclin (PGX) synthesis since these compounds are likely to be the potent biological derivatives of prostaglandin biosynthesis. Because of some recent studies, peroxidative reactions have been detailed; their intervention in prostaglandin biosynthesis is of importance and could explain some regulatory aspects of this process, as well as the action of several cofactors and prostaglandin synthetase inhibitors.