Facile and Green Chemistry Access to 5‐aryl‐1,2,4‐Triazolidine‐3‐thiones in Aqueous Medium

Abstract

Abstract A clean, cost‐effective and very practical approach has been disclosed for the one‐pot, cyclo condensation of aromatic aldehydes with different thiosemicarbazides in aqueous ethanol leading to pharmaceutically diverse 5‐aryl‐1,2,4‐triazolidine‐3‐thiones in good yields under neutral reaction conditions. Simple operational procedure, high product yield, rapid and use of green solvent system make this protocol economical as well as environmentally benevolent.