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Lung function studies in asymptomatic individuals with moderately (Pi SZ) and severely (Pi Z) reduced levels of alpha1-antitrypsin.
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1976
Year
AsthmaInflammatory Lung DiseaseAdvanced Lung DiseaseLung InflammationPulmonary Alveolar ProteinosisPhenotype Pi ZPi ZZ PhenotypesAllergyPulmonary FibrosisPulmonary MedicineLung CancerPi SzPulmonary DiseasePulmonary Vascular DiseasePhenotype Pi SzPhysiologyPulmonary PhysiologyLung MechanicsMedicineLung Function Studies
Extensive physiological evaluation of lung function were conducted in two groups of asymptomatic individuals with deficiencies of alpha1-antitrypsin: seven subjects with phenotype Pi SZ and six subjects with phenotype Pi Z. Four symptomatic individuals of Pi Z type were also investigated. The asymptomatic individuals of both SZ and Z phenotypes revealed reduction of elastic recoil, hypoventilation and hypoperfusion of the lung bases with increased closing and nitogen wash-out volumes. No signs of bronchial obstruction were observed. The asymptomatic Pi SZ subjects revealed as many signs of subclinical disease as did the asymptomatic Pi Z subjects. These data suggest that Pi SZ subjects are at increased risk of emphysema similar to Pi Z subjects.