Concepedia

Radiolabeled analogs of neurotensin (8–13) containing multiple 1,2,3-triazoles as stable amide bond mimics in the backbone

Alba Mascarin, Ibai E. Valverde, Thomas L. Mindt

MedChemComm · 2016 · 13 citations · 23 references

DOI

Concepts

Abstract

Substitution of multiple amide bonds by metabolically stable 1,2,3-triazoles yields novel tumour-targeting neurotensin-based peptidomimetics with interesting biological properties.

References

23

A Stepwise Huisgen Cycloaddition Process: Copper(I)-Catalyzed Regioselective “Ligation” of Azides and Terminal Alkynes

Vsevolod V. Rostovtsev, Luke G. Green, Valery V. Fokin et al. · Angewandte Chemie International Edition · 2002 · 11.5K citations

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Polytriazoles as Copper(I)-Stabilizing Ligands in Catalysis

Timothy R. Chan, Robert Hilgraf, K. Barry Sharpless et al. · Organic Letters · 2004 · 1.5K citations

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1,2,3-Triazoles as peptide bond isosteres: synthesis and biological evaluation of cyclotetrapeptide mimics

Victoria D. Bock, Dave Speijer, Henk Hiemstra et al. · Organic & Biomolecular Chemistry · 2007 · 283 citations

, , +17

1,2,3‐Triazoles in Peptidomimetic Chemistry

Daniel Sejer Pedersen, Andrew D. Abell · European Journal of Organic Chemistry · 2011 · 280 citations

, , +13

1,2,3‐Triazoles as Amide Bond Mimics: Triazole Scan Yields Protease‐Resistant Peptidomimetics for Tumor Targeting

Ibai E. Valverde, Andreas Bauman, Christiane A. Kluba et al. · Angewandte Chemie International Edition · 2013 · 174 citations

, , +17