Publication | Closed Access
Comparative Toxicity of 3,4,3-LIHOPO and DTPA in Baboons: Preliminary Results
16
Citations
0
References
1994
Year
PharmacokineticsComparative ToxicologyLaboratory Animal StudyToxicological MechanismElectron MicroscopyToxicologyHepatotoxicityToxicological AspectComparative ToxicityHealth SciencesAnimal PhysiologyAllergyLiver PhysiologyPoisoningRenal PathophysiologyExperimental ToxicologyPharmacologyDrug-induced Liver InjuryComparative StudyHepatologyPhysiologyMedicineNephrologyLiver Toxicity
Preliminary results are given on a comparative study of kidney and liver toxicity induced by the administration of DTPA or 3,4,3-LIHOPO to baboons. The chelating agents were administered intravenously on day 0 and then intramuscularly on days 3, 6, 9, 16, 20, 23 and 26. Individual animals were administered with 30 µmol.kg-1 DTPA, 3 or 30 µmol.kg-1 3,4,3-LIHOPO. Two untreated baboons were used as controls. Animals were housed in individual metabolic cages for 24h before treatment and 7 d after treatment in order to collect urine and blood for measurements of biochemical parameters. Kidney and liver biopsies were performed 8 d after the treatment. The tissue samples were examined by light and electron microscopy. The results obtained suggest that the different chelate treatments did not alter the function and cytology of the kidney and liver in the baboons.