PubMed · 1984 · 22 citations · 0 references
Life SciencesBiochemistryPhysiologyRedox BiochemistryAntioxidant DefenseEndothelial DysfunctionLipid PeroxidationOxidative Damage To BiomoleculesOxidative StressReactive Oxygen SpeciesEndothelial Cell DamageEndothelial Cell PhysiologyNa-k-atpase ActivityOxidative Stress InjuryPulmonary Oxidative StressSuperoxide Dismutase Function
Oxygen-derived free radicals have been shown to alter endothelial cell functions in lung. Enzymatically generated superoxide anions inactivated (Na + K)ATPase activity and caused lipid peroxidation in lung. Superoxide dismutase or allopurinol, but not ATP, protected this oxy radical-mediated depression of ATPase activity.