Concepedia

Publication | Open Access

Germ line variants predispose to both JAK2 V617F clonal hematopoiesis and myeloproliferative neoplasms

DOIFull Paper Access

260

Citations

56

References

2016

Year

David A. Hinds, Kimberly E. Barnholt, Ruben A. Mesa, Amy K. Kiefer, Nicholas Eriksson, Joanna L. Mountain, Uta Francke, Joyce Y. Tung, Huong Nguyen, Haiyu Zhang,
Blood

Abstract

Key Points Germ line variants in TERT, SH2B3, TET2, ATM, CHEK2, PINT, and GFI1B are associated with JAK2 V617F clonal hematopoiesis and MPNs. Age-related JAK2 V617F clonal hematopoiesis is found in ∼2 out of 1000 individuals in the general population.

References

YearCitations

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