[Inhibitory effect of paeonol on experimental atherosclerosis in quails].

Abstract

OBJECTIVE: To study the effect of paeonol on experimental atherosclerosis in quails caused by high lipid feeding. METHOD: The effects of oral administration of 300 and 600 mg/kg of paeonol on lipid levels in serum, hemorrheology and aortic intimal abnormalities were investigated. RESULT: Paeonol decreased TC, TG, LDL, vLDL, APOB100 levels in serum and TC levels in aorta and liver. The ratios of HDL/TC, HDL2/HDL3, apoA1/apoB100 were elevated. In addition, the drug reduced the whole blood viscosity, Plasma viscosity and plasma fibrinogen, and inhibited erythrocyte aggregation. CONCLUSION: Oral administration of paeonol can reduce the development of atherosclerosis.