β-Amyloid-Acetylcholine Molecular Interaction: New Role of Cholinergic Mediators in Anti-Alzheimer Therapy?

Abstract

Our data provide evidence that acetylcholine favors the soluble peptide conformation and exerts a neuroprotective effect against the neuroinflammatory and toxic effects of Aβ. The present paper paves the way toward the development of new polyfunctional anti-Alzheimer therapeutics capable of intervening on both the cholinergic transmission and the Aβ aggregation.