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Targeted disruption of BMP signaling through type IA receptor (BMPR1A) in osteocyte suppresses SOST and RANKL, leading to dramatic increase in bone mass, bone mineral density and mechanical strength

MechanobiologyType Ia ReceptorSclerostinDramatic IncreaseOrthopaedic SurgeryBone Morphogenic ProteinOsteoarthritisBone MassOsteoporosisMedicineCell BiologyCell SignalingBone MetabolismOsteocalcin