Concepedia

Species differences in platelet aggregation induced by platelet-activating factor (PAF).

Koji Shinozaki, Tomio Kawasaki, Junichi Kambayashi, Masato Sakon, Eiichi Shiba, Ming-Che Ou, Takahiro Mori

PubMed · 1992 · 12 citations · 0 references

Concepts

MedicineAnimal SciencesComparative PharmacologyHemostasisRabbit MedicinePlatelet ActivationPlatelet AggregationPlatelet FunctionPlatelet PhysiologyAdenosine Diphosphate-induced Platelet AggregationAssayBiological Assay DevelopmentPlatelet Activation AssaysPlatelet AggregometrySpecies Sensitivity DifferencesWashed Platelets

Abstract

Species differences in platelet aggregation induced by platelet-activating factor (PAF) were investigated by using the same procedure of platelet preparation and biological assay. Washed platelets of six different species (horses, dogs, rats, rabbits, sheep and guinea pigs) were prepared employing the same method and platelet aggregation was induced by C16-PAF. Horse platelets were most sensitive to PAF (8.0 x 10(-12) M) and rabbit platelets activated by 5.0 x 10(-11) M PAF were also sensitive enough to detect PAF in clinical samples.