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Effect of linoleic acid hydroperoxide on uptake of low density lipoprotein by cultured smooth muscle cells from rabbit aorta.
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1984
Year
Low Density LipoproteinCardiovascular DiseaseBiochemistryLinoleic Acid HydroperoxideMedicinePhysiologyLipid PeroxidationEndothelial DysfunctionHyperlipidemiaVascular BiologyLipoprotein MetabolismMetabolismPharmacologyAtherosclerosisDyslipidemiaRabbit AortaOxidative Stress
The uptake of 125I-labelled low density lipoprotein by cultured smooth muscle cells from rabbit aorta was increased by linoleic acid hydroperoxide (3-6 nmol/ml); both the binding and the degradation of the low density lipoprotein were increased. These effects could be principally ascribed to the interaction of the hydroperoxide with the cells.