Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome - Concepedia

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Publication | Open Access

Clinical Trial of the Protein Farnesylation Inhibitors Lonafarnib, Pravastatin, and Zoledronic Acid in Children With Hutchinson-Gilford Progeria Syndrome

DOI Full Paper Access

154

Citations

30

References

2016

Year

Leslie B. Gordon, Monica E. Kleinman, Ralph B. D’Agostino, Heather M. Shappell, Marie Gerhard‐Herman, Leslie Smoot, Catherine M. Gordon, Robert Cleveland, Ara Nazarian, Brian D. Snyder,

Abstract

URL: http://www.clinicaltrials.gov. Unique identifiers: NCT00879034 and NCT00916747.

References

	Year	Citations
Association of serum phosphorus and calcium x phosphate product with mortality risk in chronic hemodialysis patients: A national study GA Block, TE Hulbert-Shearon, Levin Nw, American Journal of Kidney Diseases HemodialysisRenal FunctionRenal DiseaseKidney FailureChronic Kidney Disease	1998	2.3K
Recurrent de novo point mutations in lamin A cause Hutchinson–Gilford progeria syndrome Maria Eriksson, W. Ted Brown, Leslie B. Gordon, Nature Point MutationsGenetic DisorderGeneticsPathogenesisPathology	2003	2.2K
Lamin A Truncation in Hutchinson-Gilford Progeria Annachiara De Sandre‐Giovannoli, Rafaëlle Bernard, Pierre Cau, Science BiologyUnicellular OrganismEngineeringData ScienceMeasurement	2003	1.4K
Accumulation of mutant lamin A causes progressive changes in nuclear architecture in Hutchinson–Gilford progeria syndrome Robert D. Goldman, Dale K. Shumaker, Michael R. Erdos, Proceedings of the National Academy of Sciences	2004	1.1K
Phenotype and Course of Hutchinson–Gilford Progeria Syndrome Melissa A. Merideth, Leslie B. Gordon, Sarah Clauss, New England Journal of Medicine	2008	734
Lamin A-dependent misregulation of adult stem cells associated with accelerated ageing Paola Scaffidi, Tom Misteli Nature Cell Biology Developmental BiologyMedicineAdult Stem CellStem Cell ResearchAdult Stem Cells	2008	506
A Human iPSC Model of Hutchinson Gilford Progeria Reveals Vascular Smooth Muscle and Mesenchymal Stem Cell Defects Jinqiu Zhang, Qizhou Lian, Guili Zhu, Cell stem cell BiologyRegenerative MedicineHuman Ipsc ModelMedicineHuman Tissue	2010	452
Combined treatment with statins and aminobisphosphonates extends longevity in a mouse model of human premature aging Ignacio Varela, Sandrine Pereira, Alejandro P. Ugalde, Nature Medicine Lifespan ExtensionHuman PrematureAgingAnti-agingGeriatrics	2008	392
Inhibiting farnesylation of progerin prevents the characteristic nuclear blebbing of Hutchinson-Gilford progeria syndrome Brian C. Capell, Michael R. Erdos, James P. Madigan, Proceedings of the National Academy of Sciences	2005	381
Clinical trial of a farnesyltransferase inhibitor in children with Hutchinson–Gilford progeria syndrome Leslie B. Gordon, Monica E. Kleinman, David T. Miller, Proceedings of the National Academy of Sciences	2012	365

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