Tumori Journal · 1982 · 31 citations · 20 references
Veterinary MedicineOncologyToxicologyCarcinogenesisHepatotoxicologyPesticide ToxicologyCarcinogenic MechanismsCarcinogenicity AssessmentCarcinogenicity Of Dietary ExposuresCarcinogenicity Of PesticidesHepatotoxicity Of PesticidesRodent ToxicologyCarcinogenic Hepatic EffectsDose-related Liver ToxicityMechanisms Of CarcinogenicityPesticide Carcinogenicity AssessmentPesticide-related Cancer Risk
DDT is a pesticide used in malaria-control programmes throughout the world. Its potential carcinogenicity was studied in MRC Porton rats (Wistar-derived) which received dietary concentrations of 0, 125, 250 and 500 parts per million DDT (technical-grade) for life. The treatment had no adverse effects on body growth or survival rate. Various types of tumours were observed in animals in all groups: exposure to DDT resulted in statistically significant increased incidence of liver-cell tumours only in female treated rats; one such tumour was observed in control rats. No metastases of these tumours were found.
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The United States Department of Agriculture *
The effect of long‐term exposure to DDT on CF‐1 mice
Lorenzo Tomatis, V. S. Turusov, Nicholas Day et al. · International Journal of Cancer · 1972 · 130 citations