PubMed · 1988 · 18 citations · 0 references
Life SciencesGeneticsImmunologyAutoimmunityClinical ImmunologyImmunogeneticsAutoimmune Disease PathogenesisAutoimmune DiseasesAutoimmune Hematologic DiseaseHistocompatibilityHla TypingMajor Histocompatibility ComplexHla Allele Frequency DistributionHla AllelesHla Autoimmune Disease AssociationsHla ImmunogeneticsHla Risk AllelesRelative Risk EstimationSerological Hla TypingSerological Typing
The distribution frequency of HLA-A and B antigens was determined in 24 Greek individuals with Adamantiades-Behçet's disease (A-BD) as well as in 280 controls. The standard NIH technique was used for tissue typing. There was an increased incidence of HLA-B5 in the patients group (75% compared to controls 32%). The calculated P corrected value was Pc less than 0.02, the relative risk (RR) was 6.23 and the aetiological fraction (EF) 0.68. This study agrees with the reported association between A-BD and HLA-B5 in other populations from the Mediterranean basin, the Middle East and Far East.