The Crosslinking of Gelatin by a Range of Hardening Agents

Abstract

AbstractEarlier kinetic studies of the crosslinking of gelatin by formaldehyde and glyoxal gave consistent relationships for the concentration dependence of the reactants. These however required the postulation of more complex chemistry than had been envisaged. Studies of tilt1 stoichiometry of these and a range of other hardening agents, showed a wide range of molecular efficiencies that did not correlate with the rates of reaction.Kinetic studies have now been extended to higher dialdehydes (Succinaldehyde, glutaraldehyde, 3- methylglutaraldehyde) and other crosslinking agents (2, 3-dihydroxy-l, 4-dioxane, 1, 3-bis- (vinylsulplumylmethyl) ether). The results again show consistent patterns of behaviour dependent on relatively complex chemistry. Some explanations for the mechanisms involved are advanced together with separate supporting chemical evidence.