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Inhibition of Monoamine Oxidase by Hypercin
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1984
Year
Medicinal ChemistryBiochemistryMedicineNatural SciencesLipid PeroxidationB Monoamine OxidaseMechanism Of ActionNeuropharmacologyPharmacotherapyType B MaoType A MaoPharmacologyMonoamine OxidaseInhibitory ActivityOxidative Stress
Hypericin from Hypericum perforatum was found to inhibit in vitro type A and B monoamine oxidase (MAO's) prepared by treating rat brain mitochondria with selective inhibitors. The inhibition of type A MAO by hypericin was higher than that of type B MAO. The inhibition was almost irreversible for both MAO types.