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Urea kinetics has limited relevance in assessing adequacy of dialysis in CAPD.
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1992
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Underestimate PcrnDialysisDialysis TherapyRenal FunctionBiostatisticsClinical OutcomesClinical ChemistryLaboratory MedicineChronic Kidney DiseaseHealth SciencesHemodialysisKidney FailureClinical NutritionUrea KineticsEnd-stage Renal DiseaseUrologyRenal DiseasePhysiologyMetabolismMedicineNephrology
The application of urea kinetics to CAPD is controversial. Additional data is presented from our recent study on this topic. Different methods of calculating KT/V and normalized protein catabolic rate (PCRN) are compared and KT/V is shown to be on average 6.5% higher when V is calculated by Watson's formulae instead of by body weight alone. This discrepancy increases with time. It is also shown that standard methods may overestimate KT and underestimate PCRN. KT/V and PCRN by these different methods do not correlate with clinical outcomes. However, if V is calculated by Watson's formulae, there is a significant excess of deaths when KT/V is under 0.5 (weekly KT/V under 1.5). Survival curves show that neither initial KT/V nor PCRN predict failure on CAPD.