Concepedia

β-Alanyl aminopeptidase-activated fluorogenic probes for the rapid identification of Pseudomonas aeruginosa in clinical samples

Linda Váradi, David E. Hibbs, Sylvain Orenga, Michèle Babolat, John D. Perry, Paul W. Groundwater

RSC Advances · 2016 · 11 citations · 10 references

DOIFull text

Open access

Concepts

Abstract

The fluorogenic self-immolative substrates<bold>8</bold>are specifically hydrolyzed by β-alanyl aminopeptidase, resulting in a 1,6-elimination and the release of the highly fluorescent hydroxycoumarins<bold>6</bold>.

References

10

Complete genome sequence of Pseudomonas aeruginosa PAO1, an opportunistic pathogen

C. Kendall Stover, X. Q. Pham, Alice L. Erwin et al. · Nature · 2000 · 4.6K citations · Full text

, , +13

<i>Pseudomonas aeruginosa</i>Bloodstream Infection: Importance of Appropriate Initial Antimicrobial Treatment

Scott T. Micek, Ann E. Lloyd, David J. Ritchie et al. · Antimicrobial Agents and Chemotherapy · 2005 · 520 citations · Full text

, , +14

Studies in detoxication. 67. The biosynthesis of the glucuronides of umbelliferone and 4-methylumbelliferone and their use in fluorimetric determination of β-glucuronidase

J. A. R. Mead, J. N. Smith, R. T. Williams · Biochemical Journal · 1955 · 213 citations · Full text

, , +6

Colonization resistance of the digestive tract: clinical consequences and implications

D. van der Waaij · Journal of Antimicrobial Chemotherapy · 1982 · 175 citations

, , +17

Fluorogenic and chromogenic substrates used in bacterial diagnostics.

M. Manafi, W. Kneifel, S Bascomb · Microbiological Reviews · 1991 · 109 citations · Full text

, , +17