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Requirement for Selenium (as Selenite) and Vitamin E (as α-Tocopherol) in Weaned Pigs: III. The Effect on the Development of the VESD Syndrome of Varying Selenium Levels in a Low-Tocopherol Diet
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1978
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NutritionWeaned PigsDietary ExposureExperimental NutritionVarying Selenium LevelsOxidative StressToxicologyPublic HealthVesd SyndromeAnimal PhysiologyVitamin ENutrient PhysiologyAllergySelenium DeficiencyAnimal NutritionNutritional ResponseMicronutrientsAnimal SciencePhysiologyNutritional ScienceMetabolismMedicine
An experiment was run comprising 30 weaned pigs in six groups. The basic diet contained traces of selenium (8 µg/kg dry solids) and tocopherol (1.4 mg α-tocopherol/kg dry solids). Control pigs and pigs given low supplements of selenium and tocopherol died or were killed in a moribund condition within a month or slightly more, showing the typical lesions of the vitamin E and selenium deficiency (VESD) syndrome. A combination of 5 mg DL-α-tocopheryl acetate/kg diet and 13 5 µg selenium/kg diet proved to provide protection against the syndrome. These two supplements are inadequate when administered separately.