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Effect of phenytoin on plasma clozapine concentrations in two patients.
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1991
Year
Molecular PharmacologyDrug InteractionsPsychoactive DrugPsychiatryPsychotic DisorderMedicinePsychotropic MedicationPsychopharmacologySchizophreniaNeuropharmacologySocial SciencesPharmacotherapyPlasma Clozapine ConcentrationsPharmacologyPsychopathologyOther DrugsAntipsychotic ClozapineSide Effect
Little is known about interactions of other drugs with the recently marketed antipsychotic clozapine. Two cases in which the addition of phenytoin caused a decrease in plasma clozapine concentrations and worsening of psychoses are described, and possible explanations are discussed.