Microscopic Venous Infiltration As Predictor Of Relapse In Renal Cell Carcinoma

Abstract

No AccessJournal of Urology1 Aug 1992Microscopic Venous Infiltration As Predictor Of Relapse In Renal Cell Carcinoma Ch. Mrstik, J. Salamon, R. Weber, and F. Stogermayer Ch. MrstikCh. Mrstik More articles by this author , J. SalamonJ. Salamon More articles by this author , R. WeberR. Weber More articles by this author , and F. StogermayerF. Stogermayer More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)36569-2AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail In a retrospective analysis at a single institution we evaluated the significance of various pathological phenomena on the disease-free survival of patients with radically resected renal cell carcinoma. Parameters considered were tumor extension (pT stage) according to the International Union Against Cancer, tumor invasion into the renal vein or vena cava (V stage), standard histological grading (G stage), nuclear grading (F stage) and microscopic venous infiltration. The pT stage had a significant impact on disease-free survival (p = 0.0004) of patients with radically resected tumors, as did G stage (p = 0.0001) and F stage (p = 0.002). In contrast to some previously reported results tumor extension to the renal vein and vena cava showed no influence on disease-free survival (p = 0.077). On the other hand, microscopic venous infiltration, defined as local tumor infiltration through all vessel structures including the endothelial layer leading to a free tumor extension into the vessel, had a significant impact on disease-free survival (p < 0.0001). When stratifying either tumor size or nuclear differentiation against microscopic venous infiltration, the latter retained a superior influence on disease-free survival (p = 0.01 and p = 0.0079, respectively). We conclude that microscopic venous infiltration is the most important predictor of relapse in renal cell carcinoma. © 1992 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byDall’Oglio M, Ribeiro-Filho L, Antunes A, Crippa A, Nesrallah L, Gonçalves P, Leite K and Srougi M (2018) Microvascular Tumor Invasion, Tumor Size and Fuhrman Grade: A Pathological Triad for Prognostic Evaluation of Renal Cell CarcinomaJournal of Urology, VOL. 178, NO. 2, (425-428), Online publication date: 1-Aug-2007.GONÇALVES P, SROUGI M, DALL’OGLIO M, LEITE K, ORTIZ V and HERING F (2018) LOW CLINICAL STAGE RENAL CELL CARCINOMA: RELEVANCE OF MICROVASCULAR TUMOR INVASION AS A PROGNOSTIC PARAMETERJournal of Urology, VOL. 172, NO. 2, (470-474), Online publication date: 1-Aug-2004.DRACHENBERG D, MENA O, CHOYKE P, LINEHAN W and WALTHER M (2018) PARENCHYMAL SPARING SURGERY FOR CENTRAL RENAL TUMORS IN PATIENTS WITH HEREDITARY RENAL CANCERSJournal of Urology, VOL. 172, NO. 1, (49-53), Online publication date: 1-Jul-2004.Van Poppel H, Vandendriessche H, Boel K, Mertens V, Goethuys H, Haustermans K, Van Damme B and Baert L (2018) Microscopic Vascular Invasion is the Most Relevant Prognosticator After Radical Nephrectomy for Clinically Nonmetastatic Renal Cell CarcinomaJournal of Urology, VOL. 158, NO. 1, (45-49), Online publication date: 1-Jul-1997.Gschwend J, Vogel U, Bader C, Mattfeldt T and Hautmann R (2018) Predictive Value of Magnetic Resonance Imaging and Computerized Tomography for Conservative Renal Surgery in an Ex Vivo Tumor Enucleation Study Followed by Step-SectioningJournal of Urology, VOL. 155, NO. 2, (451-454), Online publication date: 1-Feb-1996.Ljungberg B, Stenling R, Osterdahl B, Farrelly E, Aberg T and Roos G (2018) Vein Invasion in Renal Cell Carcinoma: Impact on Metastatic Behavior and SurvivalJournal of Urology, VOL. 154, NO. 5, (1681-1684), Online publication date: 1-Nov-1995.Marroncle M, Irani J, Dore B, Levillain P, Goujon J and Aubert J (2018) Prognostic Value of Histological Grade and Nuclear Grade in Renal AdenocarcinomaJournal of Urology, VOL. 151, NO. 5, (1174-1176), Online publication date: 1-May-1994. Volume 148Issue 2 Part 1August 1992Page: 271-274 Advertisement Copyright & Permissions© 1992 by The American Urological Association Education and Research, Inc.Keywordskidney neoplasmsveinscarcinomarenal cellvenae cavaeneoplasm metastasisMetricsAuthor Information Ch. Mrstik More articles by this author J. Salamon More articles by this author R. Weber More articles by this author F. Stogermayer More articles by this author Expand All Advertisement PDF downloadLoading ...