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Benzo-gamma-pyrone analogues of geiparvarin: synthesis and biological evaluation against B16 melanoma cells.
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1993
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Microm ConcentrationMedicinal ChemistryChemoprevention StrategyH ExposureMedicineB16 Melanoma CellsMelanomaMechanism Of ActionPharmacotherapyBiological EvaluationAnti-cancer AgentDrug DevelopmentPharmacologyRadiation OncologyPharmaceutical ChemistryTumor BiologyDrug DiscoveryXanthone Analogues
Chromone, flavone and xanthone analogues of geiparvarin (1) are described. Compounds 2a and 2b are more active in inhibiting the proliferation of F10 metastatic murine melanoma cells. In particular, 2a is 13 times more active at microM concentration after 48 h exposure.