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The role of the extracellular matrix in tumor cell metastasis.
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1994
Year
Tumor InnervationBiological MicroenvironmentsPathologyExtracellular MicrovesiclesCancer BiologyCellular PhysiologyTumor BiologyCancer Cell BiologyMatrix BiologyMatrix ComponentsRadiation OncologyCancer ResearchMetastatic PotentialCell BiologyTumor MicroenvironmentCell-matrix InteractionExtracellular Matrix BiologyCell MigrationMedicineExtracellular Matrix
The extracellular matrix is a macromolecular network that surrounds cells and makes up a significant portion of their microenvironment. During the processes of invasion and metastasis, tumor cells encounter interstitial stroma and basement membranes many times. In fact, tumor cell response to extracellular matrix components appears to be a major determinant of metastatic potential.