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The role of lipid peroxidation and calcium in galactosamine induced toxicity in the rat liver.
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1993
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Lipid PeroxidationLipid PeroxidesRedox BiologyToxicological MechanismOxidative StressToxicologyHepatotoxicityHealth SciencesBiochemistryLiver PhysiologyReactive Oxygen SpecieExperimental ToxicologyPharmacologyDrug-induced Liver InjuryRat LiverLiver HomogenateHepatologyPhysiologyMetabolismMedicine-Atpase Activity
Liver homogenate and subcellular fractional levels of lipid peroxides, homogenate glutathione (GSH) and calcium contents and hepatic plasma membrane Ca(2+)-ATPase activity were determined in rats, 12, 18, 24 and 48 hours after treatment with a single dose of 1 g/kg galactosamine. Lipid peroxides and calcium levels in liver homogenate and subcellular fractions were found to increase, but hepatic GSH content and Ca(2+)-ATPase activity were observed to decrease reversibly.