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Factor VII: its Turnover Rate and its Possible Role in Thrombogenesis
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1960
Year
Factor ViiPathologyPharmacotherapyLogistic AnalysisInflammationThrombosisHematologyClinical EpidemiologyPossible RolePublic HealthPlatelet AntagonistHourly Turnover RateLaboratory MedicineCell SignalingAtherosclerosisFibrinolysisVascular BiologyCell BiologyTurnover RateThrombopoiesisCardiovascular DiseaseBlood PlateletRapid Turnover RateHemostasisCoagulopathyMedicineAnticoagulant
Summary The range of the hourly turnover rate of factor VII, found in 17 normal individuals, 14 patients with thrombo-embolic diseases and 3 patients with congential hypoproconvertinaemia, was 11.1—16.6% of the total body pool of factor VII (mean normal value 13.8%). The possible significance of this rapid turnover rate of factor VII in prophylactic anticoagulant treatment with 4-hydroxycoumarin derivatives is stressed.