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Bioavailability of digoxin tablets
30
Citations
0
References
1973
Year
Therapeutic Drug MonitoringPharmaceutical SciencePharmacokinetic ModelingDigoxin TabletsDissolution RateBioequivalenceDissolution RatesPharmacological StudyPharmacologyToxicologyPharmacotherapyBiologic AvailabilityClinical ChemistryMedicinePharmacokineticsPharmacodynamic ModelingDrug Analysis
The absorption of a commercial digoxin tablet preparation of low and one of high therapeutic potency and of digoxin dissolved in alcohol was studied in digitalized patients and compared with the dissolution rates of the tablets. Biologic availability was estimated by measuring the area beneath the plasma digoxin curve. The bioavailability of the “low potency” tablet was markedly inferior to that of the “high potency” tablet, which did not differ significantly from that of digoxin in alcoholic solution. A significant correlation between bioavailability and the dissolution rate was found (p < 0.001). lt is suggested that measurement of the dissolution rate might be used as a guide to the biologic availability of a particular digoxin tablet preparation.