Fatal liver necrosis associated with the use of nitrofurantoin.

Abstract

has been recognized as playing a major role in the pathogenesis of autoimmune diseases (mechanisms) [1]. A polyclonal antibody response is mounted against thymus-independent antigen, causing a large number of B cells to proliferate and mature into antibody-forming cells independent of antigen stimulation. In addition, PSP was found to interact with the complement system in a complex manner, inhibiting both classical and alternative pathways of complement activation [4]. It is known that antibody-dependent cell-mediated cytotoxicity and natural killing are inhibited by PSP [5]. Many environmental agents have been implicated in inducing autoimmune diseases, including ultraviolet radiation, infections, drugs, and smoking [1]. It is indeed plausible to consider PSP as an environmental agent that acted as a ``trigger'' factor causing the immune state of our patient.