Effects of inhibitors on mitochondrial <scp>d</scp>-α-hydroxy acid dehydrogenase

Abstract

Previous papers (Tubbs & Greville, 1959; Tubbs, 1960a; Tubbs & Greville, 1961) have reported properties of a D-o-hydroxy acid dehydrogenase extracted in soluble form from acetone-dried rabbit-kidney mitochondria. An account of some studies on this enzyme has been presented else- where (Tubbs, 1960b), and various effects of metal- complex-forming agents on the activity of the enzyme have been the basis of a suggestion that the dehydrogenase contains a metal component near to, or actually at, the substrate-binding site (Tubbs, 1960c). This paper is devoted to the action of various types of inhibitors on the activity of the enzyme.