Circulating miR-126 and miR-499 Reflect Progression of Cardiovascular Disease; Correlations with Uric Acid and Ejection Fraction

Abstract

In patients undergoing CABG, circulating miR-126/499 is associated with presentation of traditional risk factors and reflects post-operative response to injury. Plasma pool of miRNAs likely reflects extracellular miRNAs which are proportional to intracellular miRNA levels. Therefore, circulating levels of these miRNAs have prognostic implications in detection of higher risk of future cardiovascular events.