PubMed · 1986 · 11 citations · 0 references
MedicinePharmacologyPharmacotherapyAutoimmunityImmunopathologyRheumatologyAutoimmune DiseasesAutoimmune Rheumatic DiseasesInflammatory ArthritisJoint DiseaseJoint InfectionsRheumatoid ArthritisAdult Respiratory Distress SyndromeCholestatic JaundiceIdiosyncratic Adverse Drug ReactionsIdiosyncratic Drug ReactionsIdiosyncratic Drug ToxicityIdiosyncratic ToxicityLegionella InfectionRheumatoid Arthritis Pharmacotherapy
A 55-year-old woman with rheumatoid arthritis in overlap with polymyositis received sulfasalazine for control of synovitis. Cholestatic jaundice, fever, urticaria and agranulocytosis developed after 20 days of treatment and culminated in fatal adult respiratory distress syndrome secondary to Legionella pneumophila. The increasing use of sulfasalazine in the therapy of rheumatoid arthritis mandates that the clinician be aware of this idiosyncratic drug reaction.