[Antitumor activity of CPT-11 against rat Walker 256 carcinoma].

Abstract

The antitumor activity of CPT-11 on rat Walker 256 carcinoma was investigated. Intraperitoneal, intravenous or oral administration of CPT-11 caused a remarkable prolongation of the life span of Wistar rat implanted with Walker 256 intraperitoneally. Intravenous injection and oral administration of CPT-11 markedly inhibited the growth of subcutaneously implanted Walker 256. CPT-11 showed a considerable antitumor activity by continuous intravenous injection against the solid type Walker 256.