The T cell receptor repertoire in psoriatic synovitis is restricted and T lymphocytes expressing the same TCR are present in joint and skin lesions.

Abstract

These data suggest that common or similar crossreactive antigens present in the 2 locations are responsible for the expansion of the same TCR-bearing T cells possibly already activated by a superantigen. This supports the hypothesis that both polyclonal and oligoclonal lymphocyte activation contribute to the initiation and persistence of psoriatic arthritis.