Prostatic tissue in a benign cystic teratoma of the ovary. Report of two cases.

Abstract

Case Descriptions Case 1. A 46-year-old nulliparous woman presented with lower abdominal pain and a palpable mass in the area of the left ovary. A left salpingooophorectomy was performed. The specimen submitted was a cystic ovarian mass measuring 6x5x3 cm and containing yellow sebaceous material, hair and solid nodules attached to its wall. The fallopian tube was unremarkable. Case 2. A 51-year-old woman (gravida 3, para 2) presented with a right ovarian mass. A right salpingo-oophorectomy yielded a cystic ovarian mass, 7x5x3 cm, that contained gritty yellow-white content mixed with hair. The wall of the cyst was focally thickened. Microscopic examination of both cysts revealed a mature cystic teratoma. The tumor was composed of different mature tissue elements such as skin, neural tissue and respiratory epithelium. In both cases well-defined nodules of benign prostatic tissue were found in the wall [Figure]. The prostatic nodules consisted of acini and ducts lined by columnar epithelium and surrounded by basal cells in a fibromuscular stroma. In case 2, mucinous glands resembling Cowper’s glands were noted. Foci of transitional epithelium and basal cell hyperplasia were seen in both cases. Immunohistochemical staining for prostate-specific antigen and prostatespecific alkaline phosphotase was strongly positive in prostatic epithelium in both cases. High molecular weight cytokeratin (34βE12) highlighted the basal cells.